301 Results for "

Astragalus complanatus Bunge var. eutrichus Hand.-Mazz.

" in MedChemExpress (MCE) Product Catalog:

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Cryptotanshinone

47 Publications Verification

Cat. No.: HY-N0174

CAS No.: 35825-57-1

Synonyms: Cryptotanshinon; Tanshinone c

Category:

Quinones Labiatae Samanea saman (Jacq.) Merr. Plants Disease Research Fields Naphthalene Quinones Cancer

Target:

STAT Autophagy

Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC₅₀ of 4.6 μM.

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Astragaloside IV

42 Cited Publications

Cat. No.: HY-N0431

CAS No.: 84687-43-4

Category:

Triterpenes Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields Cancer

Target:

MMP ERK JNK

Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.

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Tanshinone IIA

37 Cited Publications

Cat. No.: HY-N0135

CAS No.: 568-72-9

Synonyms: Dan Shen ketone

Category:

Quinones Labiatae Terpenoids Samanea saman (Jacq.) Merr. Diterpenoids Plants Disease Research Fields Naphthalene Quinones Cancer

Target:

VEGFR

Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.

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Geniposide

20 Cited Publications

Cat. No.: HY-N0009

CAS No.: 24512-63-8

Category:

Iridoids Terpenoids Rubiaceae Plants Gardenia jasminoides Ellis

Target:

Amyloid-β Influenza Virus

Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.

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Dihydrotanshinone I

14 Cited Publications

Cat. No.: HY-N0360

CAS No.: 87205-99-0

Category:

Cardiovascular Disease Quinones Labiatae Samanea saman (Jacq.) Merr. Plants Phenanthrenequinones Disease Research Fields

Target:

SARS-CoV

Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.

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Chaetocin

10 Cited Publications

Cat. No.: HY-N2019

CAS No.: 28097-03-2

Category:

Infection Alkaloids Microorganisms Disease Research Fields Alkaloid Dimers

Target:

Histone Methyltransferase Bacterial Antibiotic

Chaetocin is a specific inhibitor of the histone methyltransferase (HMT) SU(VAR)3-9 with an IC₅₀ of 0.6 μM for SU(VAR)3-9. It also inhibits thioredoxin reductase (TrxR) with an IC₅₀ of 4 μM.

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Periplocin

6 Cited Publications

Cat. No.: HY-N1381

CAS No.: 13137-64-9

Category:

Asclepiadaceae Plants Periploca sepium Bunge Disease Research Fields Inflammation/Immunology Steroids

Target:

Apoptosis

Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase .

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Sarsasapogenin

4 Cited Publications

Cat. No.: HY-N0073

CAS No.: 126-19-2

Synonyms: Parigenin; Sarsagenin

Category:

Liliaceae Metabolic Disease Anemarrhena asphodeloides Bunge Plants Endogenous metabolite Disease Research Fields Inflammation/Immunology Steroids

Target:

Endogenous Metabolite NF-κB

Sarsasapogenin is a sapogenin from the Chinese medical herb Anemarrhena asphodeloides Bunge, with antidiabetic, anti-oxidative, anticancer and anti-inflamatory activities.

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Danthron

4 Cited Publications

Cat. No.: HY-B0923

CAS No.: 117-10-2

Synonyms: Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone

Category:

Quinones Labiatae Anthraquinones Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Disease Research Fields Cancer

Target:

AMPK Autophagy Bacterial Virus Protease

Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.

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Corosolic acid

4 Cited Publications

Cat. No.: HY-N0280

CAS No.: 4547-24-4

Synonyms: Colosolic acid

Category:

Triterpenes other families Terpenoids Plants Disease Research Fields Cancer

Target:

Autophagy Apoptosis EGFR

Corosolic acid (Colosolic acid) isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity. Corosolic acid induces cancer cell apoptosis .

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Rhamnocitrin

3 Cited Publications

Cat. No.: HY-N1353

CAS No.: 569-92-6

Category:

Cardiovascular Disease Flavonols other families Flavonoids Phenols Polyphenols Plants Disease Research Fields

Target:

Free Radical Scavengers p38 MAPK

Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC₅₀=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) .

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Methylnissolin-3-O-glucoside

2 Cited Publications

Cat. No.: HY-N2473

CAS No.: 94367-42-7

Category:

Flavonoids Leguminosae Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields Inflammation/Immunology Other Flavonoids

Target:

Others

Methylnissolin-3-O-glucoside (Methylnissolin-3-O-β-D-glucoside) is a flavonoid from the roots of Astragalus membranaceus with anti-inflammatory effects .

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Astragaloside III

2 Cited Publications

Cat. No.: HY-N0434

CAS No.: 84687-42-3

Category:

Triterpenes other families Leguminosae Terpenoids Other Diseases Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields

Target:

C-type Lectin-like Receptors (CTLRs) Apoptosis Dengue Virus

Astragaloside III is a triterpenoid saponin. Astragaloside III can be extracted from Astragalus root. Astragaloside III increases NKG2D and induces TACE phosphorylation. Astragaloside III induces Apoptosis. Astragaloside III has antiviral activity against dengue serotypes 1 and 3. Astragaloside III has anticancer activity against breast and colon cancer .

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Glaucocalyxin A

2 Cited Publications

Cat. No.: HY-N2112

CAS No.: 79498-31-0

Category:

Labiatae Terpenoids Diterpenoids Plants Glycyrrhiza lepidota Pursh Disease Research Fields Cancer

Target:

PI3K Akt Apoptosis

Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect .

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Astragaloside II

2 Cited Publications

Cat. No.: HY-N0433

CAS No.: 84676-89-1

Synonyms: Astrasieversianin VIII

Category:

Triterpenes Leguminosae Terpenoids Other Diseases Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields

Target:

Autophagy Interleukin Related HIF/HIF Prolyl-Hydroxylase SOD NF-κB

Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, p-IκB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis .

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3,7,4'-Trihydroxyflavone

2 Cited Publications

Cat. No.: HY-111806

CAS No.: 2034-65-3

Purity: 99.44%

Synonyms: 5-Deoxykampferol; Resokaempferol

Category:

Flavonols Rhus chinensis Mill. Plants Simaroubaceae Flavonoids Other Diseases Phenols Polyphenols Disease Research Fields Anacardiaceae Brucea javanica (L.) Merr.

Target:

Reactive Oxygen Species (ROS) Leukotriene Receptor DNA/RNA Synthesis

3,7,4'-Trihydroxyflavone (5-Deoxykampferol) is a flavonoid compound that can be isolated from the stems of Rhus javanica var. roxburghiana. 3,7,4'-Trihydroxyflavone has the effect of cleaving DNA in the presence of copper ions. 3,7,4'-Trihydroxyflavone also has anti-inflammatory and antioxidant activities and can scavenge various reactive oxygen species (ROS) and reactive nitrogen species (RNS) .

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Isoastragaloside I

2 Cited Publications

Cat. No.: HY-N0887

CAS No.: 84676-88-0

Synonyms: Isoastragaloside-I

Category:

Triterpenes other families Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Metabolic Disease Plants Disease Research Fields

Target:

Akt NF-κB p38 MAPK PI3K FXR Keap1-Nrf2 NO Synthase COX Interleukin Related Integrin TGF-β Receptor Reactive Oxygen Species (ROS)

Isoastragaloside I is a natural compound found in Astragalus membranaceus, with oral activity and multiple biological activities such as anti-inflammatory and antioxidant properties. Isoastragaloside I inhibits Akt, NF-κB, MAPKs and PI3K, enhances the activity of hepatic FXR, regulates the TGF-β/Smads signaling pathway, and upregulates antioxidant molecules downstream of Nrf2. Isoastragaloside I inhibits the expression of NO, TNF-α, iNOS, COX-2, IL-1β and VCAM-1, and reduces intracellular ROS levels. Isoastragaloside I attenuates blood-brain barrier disruption, restores intestinal barrier function, increases β-cell mass, improves glucose homeostasis, and elevates circulating adiponectin levels. Isoastragaloside I can be used for the study of neuroinflammation-related neurodegenerative diseases, cholestatic liver disease, and diabetes .

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Escin IA

1 Cited Publications

Cat. No.: HY-N0554

CAS No.: 123748-68-5

Category:

Infection Triterpenes other families Hippocastanaceae Terpenoids Aesculus hippocastanum Plants Disease Research Fields Cancer

Target:

HIV Protease Monoamine Oxidase

Escin IA is an oral LOXL2 inhibitor and EMT inhibitor, with selectivity for LOXL2-expressing cells. Escin IA suppresses invasion, migration, and metastasis of breast cancer cells, and acts as the primary anti-TNBC metastasis constituent of Aesculus chinensis Bunge fruit saponin fraction. Escin IA can be used for the research of triple-negative breast cancer, acute inflammation, and ethanol-induced gastric mucosal lesions .

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Erythrinin C

1 Cited Publications

Cat. No.: HY-N3857

CAS No.: 63807-85-2

Category:

Flavonoids Leguminosae Erythrina suberosa Roxb. Plants Isoflavones

Target:

Others

Erythrinin C is an isoflavones that can be isolated from Erythrina suberosa var .

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Validamycin A

1 Cited Publications

Cat. No.: HY-B0856

CAS No.: 37248-47-8

Category:

Infection Microorganisms Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics

Target:

Fungal Tyrosinase Antibiotic

Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1?μg/mL . Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC₅₀ of 72 μM . Validamycin A is a reversible tyrosinase inhibitor, with a K_i of 5.893 mM .

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